Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Background Animal studies show that peripheral inflammatory stimuli may activate
microglial cells in the brain implicating an important role for microglia in sepsis-associated …

Vascular cognitive impairment (VCI) or vascular dementia occurs as a result of brain
ischemia and represents the second most common type of dementia after Alzheimer's …

Importance Identifying risk factors for increased β-amyloid (Aβ) deposition is important for
targeting individuals most at risk for developing Alzheimer disease and informing clinical …

Background: Hypertension is an established risk factor for stroke and vascular dementia but
recent meta-analyses examining the association between Alzheimer's disease (AD) and …

Although epidemiological data associate hypertension with a strong predisposition to
develop Alzheimer disease, no mechanistic explanation exists so far. We developed a …

Modern day cardiac surgery evolved upon the advent of cardiopulmonary bypass machines
(CPB) in the 1950s. Following this development, cardiac surgery in recent years has …

Hypertension is the single most important risk factor for cardiovascular disease and, thus,
remains a global public health challenge. Significant progress has been made during the …

Alzheimer's disease, the most common type of dementia among older adults, currently
cannot be prevented or effectively treated. Only a very small percentage of Alzheimer's …