Metformin: a novel weapon against inflammation

B Bai, H Chen - Frontiers in pharmacology, 2021 - frontiersin.org
It has become widely accepted that inflammation is a driving force behind a variety of
chronic diseases, such as cardiovascular disease, diabetes, kidney disease, cancer …

Nuclear and radiological emergencies: biological effects, countermeasures and biodosimetry

E Obrador, R Salvador-Palmer, JI Villaescusa… - Antioxidants, 2022 - mdpi.com
Atomic and radiological crises can be caused by accidents, military activities, terrorist
assaults involving atomic installations, the explosion of nuclear devices, or the utilization of …

Metformin alleviates LPS-induced acute lung injury by regulating the SIRT1/NF-κB/NLRP3 pathway and inhibiting endothelial cell pyroptosis

Y Zhang, H Zhang, S Li, K Huang, L Jiang… - Frontiers in …, 2022 - frontiersin.org
Acute respiratory distress syndrome (ARDS), a devastating complication of numerous
conditions, is often associated with high mortality. It is well known that endothelial cell (EC) …

Radiation‐induced myocardial fibrosis: mechanisms underlying its pathogenesis and therapeutic strategies

B Wang, H Wang, M Zhang, R Ji, J Wei… - Journal of Cellular …, 2020 - Wiley Online Library
Radiation‐induced myocardial fibrosis (RIMF) is a potentially lethal clinical complication of
chest radiotherapy (RT) and a final stage of radiation‐induced heart disease (RIHD). RIMF is …

Radiation-induced cardiovascular disease: mechanisms, prevention, and treatment

E Koutroumpakis, A Deswal, SW Yusuf, J Abe… - Current oncology …, 2022 - Springer
Abstract Purpose of Review Despite the advancements of modern radiotherapy, radiation-
induced cardiovascular disease (RICVD) remains a common cause of morbidity and …

Novel iodoquinazolinones bearing sulfonamide moiety as potential antioxidants and neuroprotectors

AM Soliman, WM Ghorab, DM Lotfy, HM Karam… - Scientific Reports, 2023 - nature.com
In a search for new antioxidants, a set of new iodoquinazolinone derivatives bearing
benzenesulfonamide moiety and variable acetamide pharmacophores 5–17 were designed …

Antioxidant activity of novel quinazolinones bearing sulfonamide: Potential radiomodulatory effects on liver tissues via NF-κB/PON1 pathway

AM Soliman, HM Karam, MH Mekkawy… - European Journal of …, 2020 - Elsevier
In order to discover new antioxidants, fifteen novel quinazolinone derivatives bearing
benzenesulfonamide moiety with variable heterocyclic tail, were synthesized and their …

[HTML][HTML] Murine models of radiation cardiotoxicity: A systematic review and recommendations for future studies

GM Walls, R O'Kane, M Ghita, R Kuburas… - Radiotherapy and …, 2022 - Elsevier
Background and purpose The effects of radiation on the heart are dependent on dose,
fractionation, overall treatment time, and pre-existing cardiovascular pathology. Murine …

The cardiac toxicity of radiotherapy–a review of characteristics, mechanisms, diagnosis, and prevention

T Wei, Y Cheng - International Journal of Radiation Biology, 2021 - Taylor & Francis
Purpose Radiation-induced heart disease (RIHD) is one of the most serious complications of
radiotherapy. The purpose of this paper is to review recent researches about cardiac toxicity …

Metformin confers longitudinal cardiac protection by preserving mitochondrial homeostasis following myocardial ischemia/reperfusion injury

J Tian, Y Zheng, T Mou, M Yun, Y Tian, Y Lu… - European Journal of …, 2023 - Springer
Purpose Myocardial ischemia–reperfusion (I/R) injury is associated with systemic oxidative
stress, cardiac mitochondrial homeostasis, and cardiomyocyte apoptosis. Metformin has …