Anti-trypanosomatid drug discovery: progress and challenges

M De Rycker, S Wyllie, D Horn, KD Read… - Nature Reviews …, 2023 - nature.com
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Current treatments to control African trypanosomiasis and one health perspective

A Venturelli, L Tagliazucchi, C Lima, F Venuti… - Microorganisms, 2022 - mdpi.com
Human African Trypanosomiasis (HAT, sleeping sickness) and Animal African
Trypanosomiasis (AAT) are neglected tropical diseases generally caused by the same …

Recent progress in diagnosis and treatment of Human African Trypanosomiasis has made the elimination of this disease a realistic target by 2030

A Álvarez-Rodríguez, BK Jin, M Radwanska… - Frontiers in …, 2022 - frontiersin.org
Human African Trypanosomiasis (HAT) is caused by unicellular flagellated protozoan
parasites of the genus Trypanosoma brucei. The subspecies T. b. gambiense is mainly …

Histone divergence in trypanosomes results in unique alterations to nucleosome structure

G Deák, H Wapenaar, G Sandoval, R Chen… - Nucleic Acids …, 2023 - academic.oup.com
Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

[PDF][PDF] Targeting the nucleotide metabolism of Trypanosoma brucei and other trypanosomatids

A Hofer - FEMS Microbiology Reviews, 2023 - academic.oup.com
African sleeping sickness, Chagas disease, and leishmaniasis are life-threatening diseases
that together affect millions of people around the world and are caused by different members …

Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents

R Ribeiro, L Costa, E Pinto, E Sousa, C Fernandes - Marine Drugs, 2023 - mdpi.com
Parasitic diseases still compromise human health. Some of the currently available
therapeutic drugs have limitations considering their adverse effects, questionable efficacy …

Development of a control strategy towards elimination of Trypanosoma evansi infection (surra) in camels in Africa

O Diall, M Desquesnes, B Faye, ML Dia, P Jacquiet… - Acta Tropica, 2022 - Elsevier
With an increasing worldwide population that presently exceeds 38 million, camels are
important source of meat, milk, and transportation of goods, in many regions of the world …

Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei

KR Francisco, L Monti, W Yang, H Park, LJ Liu… - Bioorganic & medicinal …, 2023 - Elsevier
Trypanosoma brucei is a protozoan parasite that causes Human African Trypanosomiasis
(HAT), a neglected tropical disease (NTD) that is endemic in 36 countries in sub-Saharan …

Emerging compounds and therapeutic strategies to treat infections from Trypanosoma brucei: an overhaul of the last 5-years patents

F Melfi, S Carradori, C Campestre… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Human African Trypanosomiasis is a neglected disease caused by
infection from parasites belonging to the Trypanosoma brucei species. Only six drugs are …

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

L Racané, L Ptiček, S Kostrun… - Journal of medicinal …, 2023 - ACS Publications
We designed and synthesized a series of symmetric bis-6-amidino-benzothiazole
derivatives with aliphatic central units and evaluated their efficacy against bloodstream …