MicroRNA-mediated regulation of glucose and lipid metabolism
P Agbu, RW Carthew - Nature reviews Molecular cell biology, 2021 - nature.com
In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …
[HTML][HTML] Monocarboxylate transporters in cancer
VL Payen, E Mina, VF Van Hée, PE Porporato… - Molecular …, 2020 - Elsevier
Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …
Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
Y Feng, Y Xiong, T Qiao, X Li, L Jia, Y Han - Cancer medicine, 2018 - Wiley Online Library
Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …
Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease
MA Felmlee, RS Jones, V Rodriguez-Cruz… - Pharmacological …, 2020 - ASPET
The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate
transporter (MCT) family that play an essential role in the transport of important cell nutrients …
transporter (MCT) family that play an essential role in the transport of important cell nutrients …
The cells of the islets of Langerhans
G Da Silva Xavier - Journal of clinical medicine, 2018 - mdpi.com
Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …
number of new studies have pointed to the potential for conversion of non-β islet cells in to …
The central role of glucokinase in glucose homeostasis: a perspective 50 years after demonstrating the presence of the enzyme in islets of Langerhans
FM Matschinsky, DF Wilson - Frontiers in physiology, 2019 - frontiersin.org
It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of
insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to …
insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to …
Targeting monocarboxylate transporters (MCTs) in cancer: how close are we to the clinics?
As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …
causing an excess production of lactate along with an increase in extracellular acidity …
Targeting lactate metabolism for cancer therapeutics
JR Doherty, JL Cleveland - The Journal of clinical …, 2013 - Am Soc Clin Investig
Lactate, once considered a waste product of glycolysis, has emerged as a critical regulator
of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate …
of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate …
Micro RNA s in metabolism
S Vienberg, J Geiger, S Madsen… - Acta …, 2017 - Wiley Online Library
Micro RNA s (mi RNA s) have within the past decade emerged as key regulators of
metabolic homoeostasis. Major tissues in intermediary metabolism important during …
metabolic homoeostasis. Major tissues in intermediary metabolism important during …
MicroRNAs in metabolism and metabolic disorders
V Rottiers, AM Näär - Nature reviews Molecular cell biology, 2012 - nature.com
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example,
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …