In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …

Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …

The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate
transporter (MCT) family that play an essential role in the transport of important cell nutrients …

Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of
insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Lactate, once considered a waste product of glycolysis, has emerged as a critical regulator
of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate …

Micro RNA s (mi RNA s) have within the past decade emerged as key regulators of
metabolic homoeostasis. Major tissues in intermediary metabolism important during …

MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example,
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …