Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the
central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is …

It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

With aging, the nervous system gradually undergoes degeneration. Increased oxidative
stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are …

Prevention of neurodegenerative diseases is presently a major goal for our Society and
melatonin, an unusual phylogenetically conserved molecule present in all aerobic …

Melatonin is a widespread molecule among living organisms involved in multiple biological,
hormonal, and physiological processes at cellular, tissue, and organic levels. It is well …

Abstract Resveratrol (3, 4', 5-trihydroxystilbene; C 14 H 12 O 3) is a polyphenolic phytoalexin
found in grapes, berries, peanuts, and wines. Resveratrol has been viewed as an …

Neurotrophic factors comprise essential secreted proteins that have several functions in
neural and non-neural tissues, mediating the development, survival and maintenance of …

Melatonin is well known for its circadian production by the pineal gland, and there is a
growing body of data showing that it is also produced by many other cells and organs …

Objectives. The goal of this study is to describe modifiable lifestyle variables associated with
reduced rate of Parkinson's disease (PD) progression. Methods. The patient‐reported …