CD4+ T cells in cancer
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
[HTML][HTML] T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
[HTML][HTML] Designing spatial and temporal control of vaccine responses
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …
However, increasing the potency, quality and durability of the vaccine response remains a …
cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity
Conventional type 1 dendritic cells (cDC1) are thought to perform antigen cross-
presentation, which is required to prime CD8+ T cells,, whereas cDC2 are specialized for …
presentation, which is required to prime CD8+ T cells,, whereas cDC2 are specialized for …
[HTML][HTML] Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms
Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …
Dendritic cells as shepherds of T cell immunity in cancer
In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …
[HTML][HTML] A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity
P Meiser, MA Knolle, A Hirschberger, GP de Almeida… - Cancer Cell, 2023 - cell.com
Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but
whether this determines protective versus ineffective anti-cancer immunity is poorly …
whether this determines protective versus ineffective anti-cancer immunity is poorly …
[HTML][HTML] Dendritic cell biology and its role in tumor immunotherapy
Y Wang, Y Xiang, VW Xin, XW Wang, XC Peng… - Journal of hematology & …, 2020 - Springer
As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor
immunotherapy. Taking into account the many recent advances in DC biology, we discuss …
immunotherapy. Taking into account the many recent advances in DC biology, we discuss …
CD4+ T cell help in cancer immunology and immunotherapy
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …
Dendritic cell subsets in T cell programming: location dictates function
SC Eisenbarth - Nature Reviews Immunology, 2019 - nature.com
Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity.
They integrate signals derived from tissue infection or damage and present processed …
They integrate signals derived from tissue infection or damage and present processed …