Children today are conceived and live in a sea of wireless radiation that did not exist when
their parents were born. The launch of the digital age continues to transform the capacity to …

Identifying “gold standard” diagnostic tests can promote evidence-based neonatology
practice. Hemolysis is a pathological shortening of the erythrocyte lifespan, differing from …

CONTEXT Severe hyperbilirubinemia is associated with kernicterus. Informed guidance on
hyperbilirubinemia management, including preventive treatment thresholds, is essential to …

Metabolic Pathway for Bilirubin in the Hepatocyte. Bilirubin-G corresponds to bilirubin
glucuronate; the donor is uridine diphosphate glucuronic acid (UDP-GA). This is catalyzed …

CONTEXT Transcutaneous bilirubinometry (TcB) is used as a valid screening to identify
neonates requiring measurement of total serum bilirubin (TSB) before phototherapy. Its use …

Since the discovery of the Rh blood group system in 1940, a greater understanding of
hemolytic disease of the fetus and newborn (HDFN) was gained. In the years thereafter …

Neonatal jaundice (NJ) is common in newborn infants. Severe NJ (SNJ) has potentially
negative neurological sequelae that are largely preventable in high resource settings if …

The diagnosis of ABO hemolytic disease of the newborn (ABO HDN) has been the subject of
considerable debate and clinical confusion. Its use as an overarching default diagnosis for …

Hemolytic disease of the fetus and newborn (HDFN) can occur when a pregnant woman has
antibody directed against an erythrocyte surface antigen expressed by her fetus. This …

Neonatal hyperbilirubinemia is an extremely common metabolic complication of the
neonatal period which may be associated with bilirubin encephalopathy and even death …