Free radicals are produced during aerobic cellular metabolism and have key roles as
regulatory mediators in signaling processes. Oxidative stress reflects an imbalance between …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Abstract “Inside every old person is a young person wondering what happened.” So, what is
aging? Aging is a manifestation of progressive, time-dependent failure of molecular …

Oxidative stress is generally considered as the consequence of an imbalance between pro-
and antioxidants species, which often results into indiscriminate and global damage at the …

Background: Redox signaling plays an important role in the lives of cells. This signaling not
only becomes apparent in pathologies but is also thought to be involved in maintaining …

Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart
failure (HF) in older adults, particularly women, and is increasing in prevalence as the …

Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle
inotropic reserve related to increased vascular afterload, arterial-ventricular load …

Progressive aging induces several structural and functional alterations in the cardiovascular
system, among whom particularly important are a reduced number of myocardial cells and …

Abstract β-Adrenergic receptors (βARs) belong to a large family of cell surface receptors
known as G protein–coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for …

It is known that there is an ongoing increase in life expectancy worldwide, especially in the
population older than 65 years of age. Cardiac aging is characterized by a series of complex …