Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like
growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 …

Injuries to the musculoskeletal system are common, debilitating and expensive. In many
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …

The regeneration of focal articular cartilage defects is complicated by the reduced quality of
the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial …

Articular cartilage is composed of chondrons within a territorial matrix surrounded by a
highly organized extracellular matrix comprising collagen II fibrils, proteoglycans …

Articular cartilage defects are prevalent and are potentially involved in the initiation of
osteoarthritis, yet the lack of efficient therapeutic options to treat cartilage defects represents …

Cartilage engineering has the potential to overcome clinical deficiency in joint disorders.
Decellularized extracellular matrix (dECM) has great biocompatibility and bioactivity and can …

Objective To investigate the effects of different doses of insulin-like growth factor 1 (IGF-1) on
the cartilage layer and subchondral bone (SB) during repair of full-thickness articular …

In orthopaedics, gene-based treatment approaches are being investigated for an array of
common-yet medically challenging-pathologic conditions of the skeletal connective tissues …

Musculoskeletal injuries involving joints, tendons, and ligaments occur commonly in the
horse, especially in those performing in athletic pursuits. Such injuries present challenges …

Osteoarthritis is a complex degenerative disease that affects the entire joint tissue. Currently,
non-surgical treatments for osteoarthritis focus on relieving pain. While end-stage …