System Xc–, also named cystine/glutamate antiporter, is an important intracellular
antioxidant element. It is composed of the light chain SLC7A11 (xCT) and the heavy chain …

Parkinson's disease is a progressive neurodegenerative disorder characterized by the
degeneration of midbrain nigral dopaminergic neurons. Although its etiology remains …

Abstract System xc− is a cystine/glutamate antiporter that exchanges extracellular cystine for
intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of …

Pituitary adenylate cyclase-activating polypeptide (PACAP) has a broad spectrum of
biological functions including neurotransmitter, neurotrophic and neuroprotective. Moreover …

Astroglial cells possess an array of cellular defense mechanisms, including superoxide
dismutase (SOD) and catalase antioxidant enzymes, to prevent damages caused by …

While pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the
hypothalamic ventromedial nuclei (VMN) has been shown to regulate feeding, a challenge …

Disruption of the glutamatergic homeostasis is commonly observed in neurological diseases
and has been frequently correlated with the altered expression and/or function of astrocytic …

Glutamate signaling is achieved by an elaborate network involving neurons and astrocytes.
Hence, it is critical to better understand how neurons and astrocytes interact to coordinate …

Background: Short-lasting hyperglycaemia occurs frequently in prediabetes and poorly
controlled diabetes mellitus leading to vascular damage. Pituitary adenylate cyclase …

Validation Assay in Cultured of a System Astrocytes xc− Functional and Nervous Tissue Samples
Page 70 ORIGINAL RESEARCH Validation Assay in Cultured of a System Astrocytes xc …