Inflammatory cytokines in atherosclerosis: current therapeutic approaches

D Tousoulis, E Oikonomou, EK Economou… - European heart …, 2016 - academic.oup.com
The notion of atherosclerosis as a chronic inflammatory disease has intensified research on
the role of cytokines and the way these molecules act and interact to initiate and sustain …

Platelets in inflammation and atherogenesis

HM Nording, P Seizer, HF Langer - Frontiers in immunology, 2015 - frontiersin.org
Platelets contribute to processes beyond thrombus formation and may play a so far
underestimated role as an immune cell in various circumstances. This review outlines …

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2

S Lucotti, C Cerutti, M Soyer… - The Journal of …, 2019 - Am Soc Clin Investig
Because metastasis is associated with the majority of cancer-related deaths, its prevention is
a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the …

Endothelial mechanobiology in atherosclerosis

X Wang, Y Shen, M Shang, X Liu… - Cardiovascular …, 2023 - academic.oup.com
Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease

FJ Pashkow, DG Watumull, CL Campbell - The American journal of …, 2008 - Elsevier
Oxidative stress and inflammation are implicated in several different manifestations of
cardiovascular disease (CVD). They are generated, in part, from the overproduction of …

Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis

JA van Diepen, JFP Berbée, LM Havekes… - Atherosclerosis, 2013 - Elsevier
Dyslipidemia and inflammation are well known causal risk factors the development of
atherosclerosis. The interplay between lipid metabolism and inflammation at multiple levels …

Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins

I Casserly, EJ Topol - The Lancet, 2004 - thelancet.com
Late-onset sporadic Alzheimer's disease is a heterogeneous disorder. In elderly patients,
increasing evidence suggests a link between this neurodegenerative disease, and vascular …

Platelets in atherosclerosis

D Lievens, P von Hundelshausen - Thrombosis and …, 2011 - thieme-connect.com
Beyond obvious functions in haemostasis and thrombosis, platelets are considered to be
essential in proinflammatory surroundings such as atherosclerosis, allergy, rheumatoid …

Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice

T Kobayashi, Y Tahara, M Matsumoto… - The Journal of …, 2004 - Am Soc Clin Investig
Production of thromboxane (TX) A2 and PG I2/prostacyclin (PGI2) is increased in patients
with atherosclerosis. However, their roles in atherogenesis have not been critically defined …

Inflammatory mechanisms in COVID-19 and atherosclerosis: current pharmaceutical perspectives

M Sagris, P Theofilis, AS Antonopoulos… - International journal of …, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has been associated with excess mortality worldwide. The …