Tuberous sclerosis is a genetic multisystem disorder characterised by widespread
hamartomas in several organs, including the brain, heart, skin, eyes, kidney, lung, and liver …

The tuberous sclerosis complex (TSC), a multisystem, autosomal dominant disorder
affecting children and adults, results from mutations in one of two genes, TSC1 (encoding …

METHODS The purpose of the LAM Task Force was to produce evidence based, consensus
guidelines for the diagnosis, assessment and treatment of patients with LAM. The two …

The lymphatic vasculature constitutes a highly specialized part of the vascular system that is
essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune …

Recently the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product has been
identified as a negative regulator of protein synthesis upstream of the mTOR and ribosomal …

Lymphangioleiomyomatosis (LAM) is a rare disease of the lungs and lymphatics, which can
occur sporadically or in association with tuberous sclerosis. LAM almost exclusively affects …

Tuberous sclerosis complex (TSC) involves abnormalities of the skin (hypomelanotic
macules, confetti skin lesions, facial angiofibromas, shagreen patches, fibrous cephalic …

Background: Understanding the true prevalence of lymphangioleiomyomatosis (LAM) is
important in estimating disease burden and targeting specific interventions. As with all rare …

Lymphangiomyomatosis (LAM) is characterized by the proliferation of abnormal smooth
muscle cells and cystic degeneration of the lung. LAM affects almost exclusively young …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the
development of widespread hamartomatous lesions in various organs, including brain, skin …