A decade ago, we hypothesized that drug addiction can be viewed as a transition from
voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by …

Background and rationale Results from many clinical studies suggest that drug relapse and
craving are often provoked by acute exposure to the self-administered drug or related drugs …

This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

The retrieval of a memory places it into a plastic state, the result of which is that the memory
can be disrupted or even enhanced by experimental treatment. This phenomenon has been …

Memory reconsolidation is the process in which reactivated long-term memory (LTM)
becomes transiently sensitive to amnesic agents that are effective at consolidation. The …

A dramatic increase in the use and dependence of prescription opioids has occurred within
the last 10 years. The consequences of long-term prescription opioid use and dependence …

Addiction is a chronic, relapsing disorder, characterised by the long-term propensity of
addicted individuals to relapse. A major factor that obstructs the attainment of abstinence is …

Retrieving a memory can modify its influence on subsequent behavior. We develop a
computational theory of memory modification, according to which modification of a memory …

Maladaptive reward memories (MRMs) are involved in the development and maintenance of
acquired overconsumption disorders, such as harmful alcohol and drug use. The process of …

Memory reconsolidation has been demonstrated in various tasks and species, suggesting it
is a fundamental process. However, there are experimental parameters that can inhibit …