A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

Viruses are nanoscale entities containing a nucleic acid genome encased in a protein shell
called a capsid and in some cases are surrounded by a lipid bilayer membrane. This review …

Extracellular vesicles (EVs) encompass a variety of vesicles secreted into the extracellular
space. EVs have been implicated in promoting tumor metastasis, but the molecular …

HIV assembly and replication proceed through the formation of morphologically distinct
immature and mature viral capsids that are organized by the Gag polyprotein (immature) …

Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases,
but the exact mechanisms of intercellular protein aggregate dissemination remain …

Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

The 5′-leader of the HIV-1 genome regulates multiple functions during viral replication via
mechanisms that have yet to be established. We developed a nuclear magnetic resonance …

Replication and pathogenesis of the human immunodeficiency virus (HIV) is tightly linked to
the structure of its RNA genome, but genome structure in infectious virions is poorly …

The incorporation of viral genomes into particles has never previously been imaged in live
infected cells. Thus, for many viruses it is unknown how the recruitment and packaging of …

Different mechanisms mediate the toxicity of RNA. Genomic retroviral mRNA hijacks infected
host cell factors to enable virus replication. The viral genomic RNA of the human …