The outbreak of COVID-19, the pandemic disease caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spurred an intense search for treatments by the …

The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge
consideration owing to their expanded applications in the field of pharmaceutical chemistry …

There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …

Angiogenesis, the formation of new blood vessels from the existing vasculature, is pivotal in
the migration, growth, and differentiation of endothelial cells in normal physiological …

Two environmentally benign methods for the synthesis of quinazolines via acceptorless
dehydrogenative coupling of 2-aminobenzylamine with benzyl alcohol (Path A) and 2 …

Three series of Spiro [(2H, 3H) quinazoline-2, 1′-cyclohexan]-4 (1H)-one derivatives have
been synthesized. Some of the novel quinazolinone derivatives IIe, VIIIc, XIc, XIIb, XIIc, XVIb …

Viruses are obligate intracellular pathogens that are dependent on cellular machineries for
their replication. Recent technological breakthroughs have facilitated reliable identification …

The serine/threonine kinase expressed by human cytomegalovirus from gene UL97
phosphorylates the antiviral drug ganciclovir, but its biological function is the …

The high cost of drug development and the narrow spectrum of coverage typically provided
by direct-acting antivirals limit the scalability of this antiviral approach. This review …

ABSTRACT AIC246 (letermovir) is a potent anticytomegalovirus drug in clinical
development. Here, we report a consistent antiviral efficacy of AIC246 against human …