This review article describes recent developments in microfluidics, with special emphasis on
disposable plastic devices. Included is an overview of the common methods used in the …

Biophysical (mechanical and electrical) properties of living cells have been proven to play
important roles in the regulation of various biological activities at the molecular and cellular …

Red blood cells (RBCs) can be cleared from circulation when alterations in their size, shape,
and deformability are detected. This function is modulated by the spleen-specific structure of …

We show the fractionation of whole blood components and isolation of blood plasma with no
dilution by using a continuous-flow deterministic array that separates blood components by …

Severe malaria by Plasmodium falciparum is a potentially fatal disease, frequently
unresponsive to even the most aggressive treatments. Host organ failure is associated with …

Traditionally, cell analysis has focused on using molecular biomarkers for basic research,
cell preparation, and clinical diagnostics; however, new microtechnologies are enabling …

Malaria resulting from Plasmodium falciparum infection is a major cause of human suffering
and mortality. Red blood cell (RBC) deformability plays a major role in the pathogenesis of …

Miniaturization to the micrometer and nanometer scale opens up the possibility to probe
biology on a length scale where fundamental biological processes take place, such as the …

Pathological processes in hematologic diseases originate at the single-cell level, often
making measurements on individual cells more clinically relevant than population averages …

This paper describes the fabrication of a microfluidic device for rapid immobilization of large
numbers of live C. elegans for performing morphological analysis, microsurgery, and …