The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

The microbiota are vital for immune homeostasis and provide a competitive barrier to
bacterial and fungal pathogens. Here, we investigated how gut commensals modulate …

Stimulator of interferon genes (STING) is essential for the type I interferon response against
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …

BACKGROUND All cells, prokaryotes and eukaryotes, release extracellular vesicles (EVs)
as part of their normal physiology and during acquired abnormalities. EVs can be broadly …

Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons
and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the …

Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the
structural similarity between those and host nucleic acids, mammalian cells have been able …

Stimulator of interferon genes (STING) is an intracellular sensor of cyclic di-nucleotides
involved in the innate immune response against pathogen-or self-derived DNA. STING …

Summary Extracellular 2′ 3′-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported
by diseased cells and imported into host cells to activate the innate immune STING pathway …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …