Background Attention-deficit/hyperactive disorder (ADHD) is a neurodevelopmental disorder
that commonly occurs in children with a prevalence ranging from 3.4 to 7.2%. It profoundly …

Autism is a behaviourally defined disorder including attenuated or abnormal social
interaction and communication, as well as aberrant repetitive behaviour, with symptoms …

The clinical efficacy and safety of a drug is determined by its activity profile across many
proteins in the proteome. However, designing drugs with a specific multi-target profile is both …

SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density (PSD) of
excitatory synapses. Small microdeletions and point mutations in SHANK3 have been …

Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by
persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction …

The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT)
ensures the phasic nature of the DA signal, which underlies the ability of DA to encode …

As discussion of stress and stress-related disorders rapidly extends beyond the brain, gut
microbiota have emerged as a promising contributor to individual differences in the risk of …

Quetiapine is an atypical antipsychotic drug that is also US FDA approved for treating
bipolar depression, albeit by an unknown mechanism. To discover the potential mechanism …

Lithium is used as treatment for bipolar disorder with particular efficacy in the treatment of
mania. Lithium inhibits glycogen synthase kinase 3β (GSK-3β) directly or indirectly via …

Parkinson's disease (PD) pathology is characterized by the formation of intra-neuronal
inclusions called Lewy bodies, which are comprised of alpha-synuclein (α-syn). Duplication …