This review describes the basics of pharmacokinetic and pharmacodynamic drug
interactions and methodological points of particular interest when designing drug interaction …

Pharmacokinetic (PK)/pharmacodynamic (PD) modeling has made an enormous
contribution to intravenous anesthesia. PK/PD models have provided us with insight into the …

We have compared bispectral index (BIS), 95% spectral edge frequency (SEF) and
approximate entropy (ApEn) in 37 patients during induction and recovery from a short …

Indicator dilution theory predicts that the first-pass pulmonary and systemic arterial
concentrations of a drug will be inversely related to the cardiac output. For high-clearance …

Background The potential benefit of propofol dose regimens that use physiologic
pharmacokinetic modeling to target the brain has been demonstrated in animals, but no data …

The new edition of this popular text has been extensively revised and updated throughout. It
will continue to provide the trainee or practising anesthetist with all the information, both …

Objective: To determine the effects of exogenous ramped infusions of epinephrine,
norepinephrine and dopamine on arterial and effluent brain blood concentrations of propofol …

Physiologically‐based pharmacokinetic (PBPK) models represent drug kinetics in one or
more 'real'organs (and hence require submodels of organs/tissues) and they describe …

Objective To evaluate the effect of rate of administration of propofol or alfaxalone on
induction dose requirements and incidence of postinduction apnea (PIA) in dogs following …

Since IV anesthetics were first used to induce general anesthesia, choosing the appropriate
dose has been a combination of the art and science of the specialty. The dramatic evidence …