Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic
characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important …

Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding
ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many …

Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …

Bones are constantly remodeled throughout life to maintain robust structure and function.
Dysfunctional remodeling can result in pathological conditions such as osteoporosis (bone …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of
the mineralized extracellular matrices of bones and teeth. OPN is characterized by the …

The term 'matricellular'has been applied to a group of extracellular proteins that do not
contribute directly to the formation of structural elements in vertebrates but serve to modulate …

Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of
osteoporosis and the assessment of fracture risk. We performed meta-analysis of five …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …