[HTML][HTML] Regulation of cancer stem cells in triple negative breast cancer

N Fultang, M Chakraborty… - Cancer Drug …, 2021 - ncbi.nlm.nih.gov
Abstract Triple Negative Breast Cancer (TNBC) is the most lethal subtype of breast cancer.
Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy …

Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures

J Dornhof, J Kieninger, H Muralidharan, J Maurer… - Lab on a Chip, 2022 - pubs.rsc.org
Three-dimensional cell cultures using patient-derived stem cells are essential in vitro
models for a more efficient and individualized cancer therapy. Currently, culture conditions …

[HTML][HTML] Trailblazing perspectives on targeting breast cancer stem cells

J Li, D Qi, TC Hsieh, JH Huang, JM Wu, E Wu - Pharmacology & …, 2021 - Elsevier
Breast cancer (BCa) is one of the most prevalent malignant tumors affecting women's health
worldwide. The recurrence and metastasis of BCa have made it a long-standing challenge …

Engineering Mesoscopic 3D Tumor Models with a Self‐Organizing Vascularized Matrix

F De Lorenzi, N Hansen, B Theek, R Daware… - Advanced …, 2024 - Wiley Online Library
Advanced in vitro systems such as multicellular spheroids and lab‐on‐a‐chip devices have
been developed, but often fall short in reproducing the tissue scale and self‐organization of …

HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell death and regulating NF-κB signaling pathway in breast cancer

Y Liang, Y Wang, Y Zhang, F Ye, D Luo, Y Li… - Cell Death & …, 2023 - nature.com
Chemoresistance is one of the major causes of therapeutic failure and poor prognosis for
breast cancer patients, especially for triple-negative breast cancer patients. However, the …

A computational systems biology approach identifies SLUG as a mediator of partial Epithelial-Mesenchymal Transition (EMT)

AR Subbalakshmi, S Sahoo, K Biswas, MK Jolly - Cells Tissues Organs, 2022 - karger.com
Epithelial-mesenchymal plasticity comprises reversible transitions among epithelial, hybrid
epithelial/mesenchymal (E/M) and mesenchymal phenotypes, and underlies various aspects …

Tumor Necrosis Factor-α (TNFα) Stimulates Triple-Negative Breast Cancer Stem Cells to Promote Intratumoral Invasion and Neovasculogenesis in the Liver of a …

H Narasimhan, F Ferraro, A Bleilevens, R Weiskirchen… - Biology, 2022 - mdpi.com
Simple Summary In this study, we investigated the effect of TNFα on primary triple-negative
breast cancer (TNBC) stem cells to understand the role of TNFα in vascular attraction in the …

Plecstatin-1 induces an immunogenic cell death signature in colorectal tumour spheroids

D Wernitznig, SM Meier-Menches, K Cseh… - Metallomics, 2020 - academic.oup.com
Organometallic metal (arene) anticancer agents were believed to confer low selectivity for
potential cellular targets. However, the ruthenium (arene) pyridinecarbothioamide (plecstatin …

HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer

G Pantelaiou-Prokaki, I Mieczkowska, GE Schmidt… - Clinical …, 2022 - Springer
Background Basal-like breast cancer (BLBC) is one of the most aggressive malignant
diseases in women with an increased metastatic behavior and poor prognosis compared to …

The potential of PSMA as a vascular target in TNBC

A Heesch, L Ortmanns, J Maurer, E Stickeler… - Cells, 2023 - mdpi.com
Recent studies proving prostate-specific membrane antigen (PSMA) expression on triple-
negative breast cancer (TNBC) cells and adjacent endothelial cells suggest PSMA as a …