Background: Inherited and sporadic medullary thyroid cancer (MTC) is an uncommon and
challenging malignancy. The American Thyroid association (ATA) chose to create specific …

Context: Over the last decade, our knowledge of the multiple endocrine neoplasia (MEN)
type 2 syndromes MEN2A and MEN2B and familial medullary thyroid carcinoma (FMTC) has …

Medullary thyroid carcinoma (MTC) is a rare type of tumor that originates from thyroid C cells
and accounts for 2–4% of all malignant thyroid neoplasms. MTC may occur sporadically or …

Multiple endocrine neoplasia type 2 is historically composed of three clinical subtypes, all of
which are associated with germline mutations in the RET proto-oncogene. Multiple …

Abstract Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant
hereditary cancer syndrome presented mostly by tumours of the parathyroids, endocrine …

The rapid technical advances in molecular biology and accelerating improvements in
genomic and proteomic diagnostics have led to increasingly personalized strategies for …

Background: Vascular endothelial growth factor (VEGF-A) expression is upregulated in the
majority of human tumors, where it stimulates proliferation, migration, and survival of …

Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary cancer
syndrome caused by missense gain-of-function mutations of the RET proto-oncogene. Three …

Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant cancer syndrome
with major components of medullary thyroid carcinoma (MTC), pheochromocytoma and …

Genetic variability in humans is influenced by many factors, such as natural selection,
mutations, genetic drift, and migrations. Molecular epidemiology evaluates the contribution …