Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Hepatocellular carcinoma (HCC) is the fourth most common primary liver tumor and is an
important medical problem worldwide. However, the use of current therapies for HCC is no …

Computational drug repositioning has been proved as an effective approach to develop new
drug uses. However, currently existing strategies strongly rely on drug response gene …

Diabetic foot ulcers (DFUs) are a common complication of diabetes and can lead to severe
disability and even amputation. Despite advances in treatment, there is currently no cure for …

Repurposing FDA-approved drugs with the aid of gene signatures of disease can accelerate
the development of new therapeutics. A major challenge to developing reliable drug …

Non-alcoholic steatohepatitis (NASH) is a rising health challenge, with no approved drugs.
We used a computational drug repositioning strategy to uncover a novel therapy for NASH …

Fusobacterium nucleatum (F. nucleatum) is a crucial periodontal pathogen and human
gingival fibroblasts (GFs) are the first line of defense against oral pathogens. However, the …

Commonly used antihistamines and other cationic amphiphilic drugs (CADs) are emerging
as putative cancer drugs. Their unique chemical structure enables CADs to accumulate …

Nanoemulsions have wide application, presenting several properties such as the
solubilization of poorly soluble drugs in water, promoting the increase of their bioavailability …

Resistance to current therapies is common for pancreatic cancer and hence novel treatment
options are urgently needed. In this work, we developed and validated a computational …