Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …
spaceflight biology that guide our current understanding of fundamental molecular changes …
Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars
ZS Patel, TJ Brunstetter, WJ Tarver, AM Whitmire… - npj …, 2020 - nature.com
NASA's plans for space exploration include a return to the Moon to stay—boots back on the
lunar surface with an orbital outpost. This station will be a launch point for voyages to …
lunar surface with an orbital outpost. This station will be a launch point for voyages to …
Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis
There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …
progression and metastasis phases. In many cases, the molecular mechanisms …
Carbon ion radiobiology
W Tinganelli, M Durante - Cancers, 2020 - mdpi.com
Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …
and Europe and is now planned in the USA. The physics advantages of carbon ions …
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …
Review of laser-driven ion sources and their applications
H Daido, M Nishiuchi… - Reports on progress in …, 2012 - iopscience.iop.org
For many years, laser-driven ion acceleration, mainly proton acceleration, has been
proposed and a number of proof-of-principle experiments have been carried out with lasers …
proposed and a number of proof-of-principle experiments have been carried out with lasers …
Heart in space: effect of the extraterrestrial environment on the cardiovascular system
RL Hughson, A Helm, M Durante - Nature Reviews Cardiology, 2018 - nature.com
National space agencies and private corporations aim at an extended presence of humans
in space in the medium to long term. Together with currently suboptimal technology …
in space in the medium to long term. Together with currently suboptimal technology …
DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation
E Mladenov, S Magin, A Soni, G Iliakis - Seminars in cancer biology, 2016 - Elsevier
Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …
biochemical pathways that enable damage recognition and initiate responses leading to …
Heavy-ion tumor therapy: Physical and radiobiological benefits
D Schardt, T Elsässer, D Schulz-Ertner - Reviews of modern physics, 2010 - APS
High-energy beams of charged nuclear particles (protons and heavier ions) offer significant
advantages for the treatment of deep-seated local tumors in comparison to conventional …
advantages for the treatment of deep-seated local tumors in comparison to conventional …
Charged particles in radiation oncology
M Durante, JS Loeffler - Nature reviews Clinical oncology, 2010 - nature.com
Radiotherapy is one of the most common and effective therapies for cancer. Generally,
patients are treated with X-rays produced by electron accelerators. Many years ago …
patients are treated with X-rays produced by electron accelerators. Many years ago …