Anti-inflammatory and anticancer effects of microalgal carotenoids

J Ávila-Román, S García-Gil, A Rodríguez-Luna… - Marine Drugs, 2021 - mdpi.com
Acute inflammation is a key component of the immune system's response to pathogens, toxic
agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing …

Resveratrol as an adjunctive therapy for excessive oxidative stress in aging COVID-19 patients

MT Liao, CC Wu, SFV Wu, MC Lee, WC Hu, KW Tsai… - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic continues to burden healthcare
systems worldwide. COVID-19 symptoms are highly heterogeneous, and the patient may be …

[HTML][HTML] Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis

S Ghosh, R Singh, ZM Vanwinkle, H Guo… - Theranostics, 2022 - ncbi.nlm.nih.gov
The survival rate of colorectal cancer patients is adversely affected by the selection of tumors
resistant to conventional anti-cancer drugs such as 5-fluorouracil (5FU). Although there is …

Natural products targeting signaling pathways associated with regulated cell death in gastric cancer: Recent advances and perspectives

Q Hu, Z Li, Y Li, X Deng, Y Chen, X Ma… - Phytotherapy …, 2023 - Wiley Online Library
Gastric cancer (GC) is one of the most serious gastrointestinal malignancies with high
morbidity and mortality. The complexity of GC process lies in the multi‐phenotypic linkage …

Long noncoding RNA PSMA3-AS1 functions as a competing endogenous RNA to promote gastric cancer progression by regulating the miR-329-3p/ALDOA axis

L Kan, M Yang, H Zhang - Biology Direct, 2023 - Springer
LncRNA PSMA3-AS1 functions as an oncogene in several cancers, including ovarian
cancer, lung cancer, and colorectal cancer. However, its role in gastric cancer (GC) …

Hawk tea flavonoids as natural hepatoprotective agents alleviate acute liver damage by reshaping the intestinal microbiota and modulating the Nrf2 and NF-κB …

T Xu, S Hu, Y Liu, K Sun, L Luo, L Zeng - Nutrients, 2022 - mdpi.com
Hawk tea (Litsea coreana Levl. var. lanuginosa) is a traditional herbal tea in southwestern
China, and was found to possess hepatoprotective effects in our previous study. However, it …

Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

L Lin, Q Wu, F Lu, J Lei, Y Zhou, Y Liu, N Zhu… - Frontiers in …, 2023 - frontiersin.org
Cancer is a borderless global health challenge that continues to threaten human health.
Studies have found that oxidative stress (OS) is often associated with the etiology of many …

[HTML][HTML] Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells

ES Bae, WS Byun, CW Ock, WK Kim, HJ Park… - Biomedicine & …, 2023 - Elsevier
Although gemcitabine-based chemotherapy is common and effective for pancreatic cancer
(PC), acquired drug resistance is one of the major reasons for treatment failure. Therefore, a …

Mitigation of cardiovascular disease and toxicity through NRF2 signalling

JA Roberts, RD Rainbow, P Sharma - International journal of molecular …, 2023 - mdpi.com
Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact
on morbidity and mortality. The pathophysiology driving the development of these conditions …

The role of concomitant Nrf2 targeting and stem cell therapy in cerebrovascular disease

J Gordon, G Lockard, M Monsour, A Alayli… - Antioxidants, 2022 - mdpi.com
Despite the reality that a death from cerebrovascular accident occurs every 3.5 min in the
United States, there are few therapeutic options which are typically limited to a narrow …