Liver sinusoidal endothelial cells—gatekeepers of hepatic immunity
Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …
Tumor immune microenvironment and immunosuppressive therapy in hepatocellular carcinoma: a review
K Oura, A Morishita, J Tani, T Masaki - International journal of molecular …, 2021 - mdpi.com
Liver cancer has the fourth highest mortality rate of all cancers worldwide, with
hepatocellular carcinoma (HCC) being the most prevalent subtype. Despite great advances …
hepatocellular carcinoma (HCC) being the most prevalent subtype. Despite great advances …
Vascular endothelial cells and innate immunity
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …
participate in both innate and adaptive immune responses. We previously reported that, in …
The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver
AL Wilkinson, M Qurashi, S Shetty - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …
The evolving role of liver sinusoidal endothelial cells in liver health and disease
MJ McConnell, E Kostallari, SH Ibrahim, Y Iwakiri - Hepatology, 2023 - journals.lww.com
LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …
Liver sinusoidal endothelial cell: an update
LD DeLeve, AC Maretti-Mira - Seminars in liver disease, 2017 - thieme-connect.com
This update focuses on two main topics. First, recent developments in our understanding of
liver sinusoidal endothelial cell (LSEC) function will be reviewed, specifically elimination of …
liver sinusoidal endothelial cell (LSEC) function will be reviewed, specifically elimination of …
Angiodiversity and organotypic functions of sinusoidal endothelial cells
PS Koch, KH Lee, S Goerdt, HG Augustin - Angiogenesis, 2021 - Springer
Abstract 'Angiodiversity'refers to the structural and functional heterogeneity of endothelial
cells (EC) along the segments of the vascular tree and especially within the microvascular …
cells (EC) along the segments of the vascular tree and especially within the microvascular …
Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
AK Horst, KG Kumashie, K Neumann, L Diehl… - Cellular & molecular …, 2021 - nature.com
The liver is an important immunological organ that controls systemic tolerance. The liver
harbors professional and unconventional antigen-presenting cells that are crucial for …
harbors professional and unconventional antigen-presenting cells that are crucial for …
New tools to prevent cancer growth and spread: a 'Clever'approach
Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on
lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes …
lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes …
Liver sinusoidal endothelial cells promote the differentiation and survival of mouse vascularised hepatobiliary organoids
The structural and physiological complexity of currently available liver organoids is limited,
thereby reducing their relevance for drug studies, disease modelling, and regenerative …
thereby reducing their relevance for drug studies, disease modelling, and regenerative …