Changing the strength of connections between neurons is widely assumed to be the
mechanism by which memory traces are encoded and stored in the central nervous system …

The contribution of glutamate to synaptic transmission, plasticity and development is well
established; current evidence is based on diverse approaches to decipher function and …

Background: To characterize further behavioral, cognitive, neuroendocrine, and
physiological effects of subanesthetic doses of ketamine hydrochloride in healthy human …

Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair
prefrontal cortex (PFC) function in the rat and produce symptoms in humans similar to those …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

It is humbling to think that 30 years have passed since the paper by Collingridge, Kehl and
McLennan showing that one of Jeff Watkins most interesting compounds, R-2-amino-5 …

Aging is associated with specific impairments of learning and memory, some of which are
similar to those caused by hippocampal damage. Studies of the effects of aging on …

N-methyl-D-aspartate (NMDA) glutamate receptor antagonists are reported to induce
schizophrenia-like symptoms in humans, including cognitive impairments. Shortcomings of …

RECEPTORS for N-methyl-d-aspartate (NMDA) seem to have a critical role in synaptic
plasticity1–4. NMDA antagonists (such as AP5) prevent induction of long-term potentiation5 …

From previous literature, it appears that most classical neurotransmitter systems can in some
way influence learning and memory in the rat. A matter of crucial interest is, however …