Adverse drug reactions across the age continuum: epidemiology, diagnostic challenges, prevention, and treatments

M Rieder - The Journal of Clinical Pharmacology, 2018 - Wiley Online Library
Adverse drug reactions (ADRs) are common and important complications of drug therapy for
children. The risk for ADRs changes over childhood, as do the nature and types of ADRs …

Antibiotic allergy

A Romano, R Warrington - Immunology and Allergy …, 2014 - immunology.theclinics.com
Antibiotics may be classified as b-lactams or non-b-lactams. b-Lactam antibiotics contain a 4-
membered b-lactam ring and consist of 2 major classes, the penicillins (penams) and …

In vitro assays in severe cutaneous adverse drug reactions: are they still research tools or diagnostic tests already?

G Porebski - International Journal of Molecular Sciences, 2017 - mdpi.com
Severe cutaneous adverse drug reactions (SCARs) represent life-threatening medical
conditions and an appropriate causative diagnosis of these conditions is of the highest …

Pharmacogenomics and adverse drug reactions in children

MJ Rieder, B Carleton - Frontiers in genetics, 2014 - frontiersin.org
Adverse drug reactions are a common and important complication of drug therapy in
children. Over the past decade it has become increasingly apparent that genetically …

In vitro testing for diagnosis of idiosyncratic adverse drug reactions: Implications for pathophysiology

AA Elzagallaai, MJ Rieder - British journal of clinical …, 2015 - Wiley Online Library
Idiosyncratic drug reactions (IDRs) represent a major health problem, as they are
unpredictable, often severe and can be life threatening. The low incidence of IDRs makes …

Anaphylaxis to drugs, biological agents, and vaccines

RH Shah, MM Kuder, DM Lang - … and Allergy Clinics, 2022 - immunology.theclinics.com
Anaphylaxis is a life-threatening systemic reaction, defined by a range of clinical
characteristics. Definitions for the diagnosis of anaphylaxis generally include acute onset …

Novel insights into molecular and cellular aspects of delayed drug hypersensitivity reactions

AA Elzagallaai, MJ Rieder - Expert Review of Clinical …, 2023 - Taylor & Francis
Introduction Delayed drug hypersensitivity reactions (DDHRs) represent a major health
problem. They are unpredictable and can cause life-long disability or even death. The …

Bridging the gap between bench and clinic: the importance of understanding the mechanism of iodinated contrast media hypersensitivity

CM Sullivan, NS Paul, MJ Rieder - The British Journal of …, 2023 - academic.oup.com
Since the advent of CT, iodinated contract media (ICM) has become one of the most
regularly administered intravenous medications in clinical settings. Although considered …

Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity

AA Elzagallaai, AM Abuzgaia, MJ Rieder - Journal of Pharmacological and …, 2024 - Elsevier
Standardization and validation of in vitro drug metabolism is essential for pre-clinical drug
development as well as for in vitro toxicity assays including the lymphocyte toxicity assay …

New ways to detect adverse drug reactions in pediatrics

M Rieder - Pediatric Clinics, 2012 - pediatric.theclinics.com
For most of recorded history, medical treatment was conducted using therapies that would
today be considered complementary or alternative medicine. 1 Medications were typically …