The evolving story of incretins (GIP and GLP‐1) in metabolic and cardiovascular disease: a pathophysiological update

MA Nauck, DR Quast, J Wefers… - Diabetes, Obesity and …, 2021 - Wiley Online Library
The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation

BA McLean, CK Wong, JE Campbell… - Endocrine …, 2021 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

[HTML][HTML] Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease

J Nowell, E Blunt, D Gupta, P Edison - Ageing Research Reviews, 2023 - Elsevier
Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

Modulation of adipocyte metabolism by microbial short-chain fatty acids

KS May, LJ den Hartigh - Nutrients, 2021 - mdpi.com
Obesity and its complications—including type 2 diabetes, cardiovascular disease, and
certain cancers—constitute a rising global epidemic that has imposed a substantial burden …

Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity

H Yaribeygi, T Sathyapalan, A Sahebkar - Life sciences, 2019 - Elsevier
Glucagon-like peptide-1 is a peptide of incretin family which is used in the management of
diabetes as glucagon-like peptide-1 receptor agonist (GLP-1RA). Dipeptidyl peptidase-4 …

Adipose tissue dysfunction in polycystic ovary syndrome

F Bril, U Ezeh, M Amiri, S Hatoum… - The Journal of …, 2024 - academic.oup.com
Purpose Polycystic ovary syndrome (PCOS) is a complex genetic trait and the most common
endocrine disorder of women, clinically evident in 5% to 15% of reproductive-aged women …

Anti-inflammatory effects of GLP-1 receptor activation in the brain in neurodegenerative diseases

Y Diz-Chaves, Z Mastoor, C Spuch… - International Journal of …, 2022 - mdpi.com
The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin
effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also …

Glucagon-like peptide-1 (GLP-1) in the integration of neural and endocrine responses to stress

Y Diz-Chaves, S Herrera-Pérez, LC González-Matías… - Nutrients, 2020 - mdpi.com
Glucagon like-peptide 1 (GLP-1) within the brain is produced by a population of
preproglucagon neurons located in the caudal nucleus of the solitary tract. These neurons …

Direct effects of glucagon on glucose uptake and lipolysis in human adipocytes

MJ Pereira, K Thombare, A Sarsenbayeva… - Molecular and cellular …, 2020 - Elsevier
We aim to investigate the expression of the glucagon receptor (GCGR) in human adipose
tissue, and the impact of glucagon in glucose uptake and lipolysis in human adipocytes …