Integrons: past, present, and future
MR Gillings - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …
The integron: adaptation on demand
The integron is a powerful system which, by capturing, stockpiling, and rearranging new
functions carried by gene encoding cassettes, confers upon bacteria a rapid adaptation …
functions carried by gene encoding cassettes, confers upon bacteria a rapid adaptation …
The genetic basis of the fitness costs of antimicrobial resistance: a meta‐analysis approach
T Vogwill, RC MacLean - Evolutionary applications, 2015 - Wiley Online Library
The evolution of antibiotic resistance carries a fitness cost, expressed in terms of reduced
competitive ability in the absence of antibiotics. This cost plays a key role in the dynamics of …
competitive ability in the absence of antibiotics. This cost plays a key role in the dynamics of …
Trade-off mechanisms shaping the diversity of bacteria
T Ferenci - Trends in microbiology, 2016 - cell.com
Strain-to-strain variations in bacterial biofilm formation, metabolism, motility, virulence,
evolvability, DNA repair and resistance (to phage, antibiotics, or environmental stresses) …
evolvability, DNA repair and resistance (to phage, antibiotics, or environmental stresses) …
Integron activity accelerates the evolution of antibiotic resistance
Mobile integrons are widespread genetic platforms that allow bacteria to modulate the
expression of antibiotic resistance cassettes by shuffling their position from a common …
expression of antibiotic resistance cassettes by shuffling their position from a common …
Integrons: vehicles and pathways for horizontal dissemination in bacteria
S Domingues, GJ da Silva, KM Nielsen - Mobile genetic elements, 2012 - Taylor & Francis
Integrons are genetic elements first described at the end of the 1980s. Although most
integrons were initially described in human clinical isolates, they have now been identified …
integrons were initially described in human clinical isolates, they have now been identified …
Conserved phylogenetic distribution and limited antibiotic resistance of class 1 integrons revealed by assessing the bacterial genome and plasmid collection
Background Integrons, especially the class 1 integrons, are major contributors to the
acquisition and dissemination of antibiotic resistance genes (ARGs). However …
acquisition and dissemination of antibiotic resistance genes (ARGs). However …
Epistasis and the evolution of antimicrobial resistance
A Wong - Frontiers in Microbiology, 2017 - frontiersin.org
The fitness effects of a mutation can depend, sometimes dramatically, on genetic
background; this phenomenon is often referred to as “epistasis.” Epistasis can have …
background; this phenomenon is often referred to as “epistasis.” Epistasis can have …
Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli
There is urgent need to develop novel treatment strategies to reduce antimicrobial
resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases …
resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases …
Class 1 integrons are low-cost structures in Escherichia coli
Y Lacotte, MC Ploy, S Raherison - The ISME Journal, 2017 - academic.oup.com
Resistance integrons are bacterial genetic platforms that can capture and express antibiotic
resistance genes embedded within gene cassettes. The capture and shuffling of gene …
resistance genes embedded within gene cassettes. The capture and shuffling of gene …