Purpose Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast
cancer that is frequently treated with chemotherapy. However, many patients exhibit either …

Epigenetics plays a key role in cancer development. Genetics alone cannot explain sporadic
cancer and cancer development in individuals with no family history or a weak family history …

Breast cancer, with a lifelong risk of one in nine, is the most common cancer among women.
In Iran, breast cancer is one of the growing and important women's health problems. Several …

Purpose DNA promoter hypermethylation of tumor suppressor genes is known to occur early
in cancer development, including breast cancer. To improve early breast cancer detection …

Pathological staging and histological grading systems are useful, but imperfect, predictors of
recurrence in head and neck squamous cell carcinoma (HNSCC). Aberrant promoter …

Identification of a single molecular trait that is determinant of common malignancies may
serve as a powerful diagnostic supplement to cancer type-specific markers. Here, we report …

Aberrations of DNA methylation are early events in the development of tumors. In this study,
we investigated the DNA methylation status of growth hormone secretagogue receptor …

Aim: To investigate GHSR and GHRL methylation in 73 pairs of colorectal cancer (CRC)
tissues and healthy adjacent mucosa. Methods: Methylation was assessed with methylation …

Genetic variations in ovulation rate which occur in different breeds of sheep provide useful
models to explore the mechanisms regulating the development of antral follicles. The …

The advent of high-throughput technologies such as microarrays, global gene knockout, and
next generation sequencing (NGS) has revolutionized the field of molecular oncology. Large …