Inflammation and inflammatory cytokine contribute to the initiation and development of ulcerative colitis and its associated cancer

D Yao, M Dong, C Dai, S Wu - Inflammatory bowel diseases, 2019 - academic.oup.com
Dysregulated inflammatory responses play a pivotal role in the initiation, development, and
progression of tumors, as demonstrated by the association between ulcerative colitis and the …

Colorectal cancer in ulcerative colitis: mechanisms, surveillance and chemoprevention

W Li, T Zhao, D Wu, J Li, M Wang, Y Sun, S Hou - Current Oncology, 2022 - mdpi.com
Patients with ulcerative colitis (UC) are at a two-to three-fold increased risk of developing
colorectal cancer (CRC) than the general population based on population-based data. UC …

TLR4 signaling in the development of colitis-associated cancer and its possible interplay with microRNA-155

J Guo, M Liao, J Wang - Cell Communication and Signaling, 2021 - Springer
Ulcerative colitis (UC) has closely been associated with an increased risk of colorectal
cancer. However, the exact mechanisms underlying colitis-associated cancer (CAC) …

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

AR Sarohan, M Kızıl, AÇ İnkaya, S Mahmud, M Akram… - Cellular signalling, 2021 - Elsevier
The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year
and a half, more than 200 million people have been infected and more than four million …

Anemoside B4 prevents acute ulcerative colitis through inhibiting of TLR4/NF-κB/MAPK signaling pathway

H Ma, M Zhou, W Duan, L Chen, L Wang… - International …, 2020 - Elsevier
Abstract Anemoside B4 (B4) is a compound extracted from Pulsatilla chinensis (P.
chinensis). Pharmacological studies have proved that it has certain anti-inflammatory …

Gut microbiota, inflammatory bowel disease, and Cancer: the role of guardians of innate immunity

V Giambra, D Pagliari, P Rio, B Totti, C Di Nunzio… - Cells, 2023 - mdpi.com
Inflammatory bowel diseases (IBDs) are characterized by a persistent low-grade
inflammation that leads to an increased risk of colorectal cancer (CRC) development …

Retinoic acid, leaky gut, and autoimmune diseases

L Abdelhamid, XM Luo - Nutrients, 2018 - mdpi.com
A leaky gut has been observed in a number of autoimmune diseases including type 1
diabetes, multiple sclerosis, inflammatory bowel disease, and systemic lupus …

Pectin oligosaccharides ameliorate colon cancer by regulating oxidative stress-and inflammation-activated signaling pathways

H Tan, W Chen, Q Liu, G Yang, K Li - Frontiers in Immunology, 2018 - frontiersin.org
Colon cancer (CC) is the third common neoplasm worldwide, and it is still a big challenge for
exploring new effective medicine for treating CC. Natural product promoting human health …

Nitric oxide (NO) and NO synthases (NOS)-based targeted therapy for colon cancer

H Wang, L Wang, Z Xie, S Zhou, Y Li, Y Zhou, M Sun - Cancers, 2020 - mdpi.com
Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy
remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its …

Curcumin inhibits the growth of liver cancer by impairing myeloid‑derived suppressor cells in murine tumor tissues

S Tian, L Liao, Q Zhou, X Huang… - Oncology …, 2021 - spandidos-publications.com
Curcumin, one of the active ingredients of Curcuma longa (Jianghuang), has been reported
to exert multiple bioactivities, including pro‑apoptotic and anti‑inflammatory activities. In …