Fisetin in cancer: attributes, developmental aspects, and nanotherapeutics

RM Kumar, H Kumar, T Bhatt, R Jain, K Panchal… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major causes of mortality, globally. Cancerous cells invade normal cells
and metastasize to distant sites with the help of the lymphatic system. There are several …

Supercritical antisolvent process for pharmaceutical applications: A review

P Franco, I De Marco - Processes, 2020 - mdpi.com
The supercritical antisolvent (SAS) technique has been widely employed in the biomedical
field, including drug delivery, to obtain drug particles or polymer-based systems of …

Preparation of pH-sensitive chitosan/polyvinylpyrrolidone/α-Fe2O3 nanocomposite for drug delivery application: Emphasis on ameliorating restrictions

SE Gerami, M Pourmadadi, H Fatoorehchi… - International Journal of …, 2021 - Elsevier
Abstract Chitosan (CS)/polyvinylpyrrolidone (PVP)/hematite (α-Fe 2 O 3) nanocomposites
loaded with Doxorubicin (drug model) were synthesized via an oil-in-water emulsification …

Electrospun coaxial fibers to optimize the release of poorly water-soluble drug

Y Liu, X Chen, Y Liu, Y Gao, P Liu - Polymers, 2022 - mdpi.com
In a drug delivery system, the physicochemical properties of the polymeric matrix have a
positive impact on the bioavailability of poorly water-soluble drugs. In this work, monolithic …

Fisetin—In search of better bioavailability—From macro to nano modifications: A review

J Szymczak, J Cielecka-Piontek - International Journal of Molecular …, 2023 - mdpi.com
As secondary plant metabolites, polyphenols are abundant in fruits and vegetables. They
are in high demand because of their many health benefits. However, their low bioavailability …

Nanoparticles and Nanocrystals by Supercritical CO2-Assisted Techniques for Pharmaceutical Applications: A Review

P Franco, I De Marco - Applied Sciences, 2021 - mdpi.com
Many active ingredients currently prescribed show limited therapeutic efficacy, mainly due to
their dissolution rate inadequate to treat the pathology of interest. A large drug particle size …

Cancer chemopreventive role of fisetin: Regulation of cell signaling pathways in different cancers

AA Farooqi, H Naureen, R Zahid, L Youssef… - Pharmacological …, 2021 - Elsevier
It is becoming progressively more understandable that pharmaceutical targeting of drug-
resistant cancers is challenging because of intra-and inter-tumor heterogeneity …

Nanoformulation development to improve the biopharmaceutical properties of fisetin using design of experiment approach

WY Liu, CC Lin, YS Hsieh, YT Wu - Molecules, 2021 - mdpi.com
This study aimed to design an effective nanoparticle-based carrier for the oral delivery of
fisetin (FST) with improved biopharmaceutical properties. FST-loaded nanoparticles were …

A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide

S Sip, N Rosiak, A Sip, M Żarowski, K Hojan… - Antioxidants, 2023 - mdpi.com
Fisetin (FIS), a senolytic flavonoid, mitigates age-related neuroprotective changes. An
amorphous FIS dispersion with a co-carrier was prepared using supercritical fluid extraction …

Supercritical fluid-assisted fabrication of C-doped Co3O4 nanoparticles based on polymer-coated metal salt nanoreactors for efficient enzyme-mimicking and …

ZW Kang, JY Zhang, ZZ Li, RK Kankala, SB Wang… - Nano Research, 2023 - Springer
Nanomaterials doped with non-metallic C have attracted tremendous attention as potential
nano-artificial enzymes due to their ability to change the energy band structure to improve …