Trapped ion mobility spectrometry: A short review

ME Ridgeway, M Lubeck, J Jordens, M Mann… - International journal of …, 2018 - Elsevier
Trapped ion mobility spectrometry (TIMS) hybridized with mass spectrometry (MS) is a
relatively recent advance in the field of ion mobility mass spectrometry (IMMS). The basic …

Using untargeted metabolomics for detecting exposome compounds

CS Bloszies, O Fiehn - Current Opinion in Toxicology, 2018 - Elsevier
The exposome is the summary of all chemical and non-chemical exposures over an
individual's lifetime that collectively describe all non-genetic factors that may influence …

Fundamentals of trapped ion mobility spectrometry part II: fluid dynamics

JA Silveira, K Michelmann, ME Ridgeway… - Journal of the …, 2016 - ACS Publications
Trapped ion mobility spectrometry (TIMS) is a new high resolution (R up to~ 300) separation
technique that utilizes an electric field to hold ions stationary against a moving gas …

Parallel accumulation for 100% duty cycle trapped ion mobility-mass spectrometry

JA Silveira, ME Ridgeway, FH Laukien, M Mann… - International Journal of …, 2017 - Elsevier
A new trapped ion mobility spectrometry (TIMS) apparatus has been developed and
evaluated. Building on the original prototype design, the new spectrometer includes an …

Proteomic characterization of seminal plasma from alternative reproductive tactics of Chinook salmon (Oncorhynchus tswatchysha)

R Gombar, TE Pitcher, JA Lewis, J Auld… - Journal of Proteomics, 2017 - Elsevier
Chinook salmon (Oncorhynchus tshawytscha) are external fertilizers that display sneak-
guard alternative reproductive tactics. The larger hooknose males dominate mating …

Biomedical applications of ion mobility-enhanced data-independent acquisition-based label-free quantitative proteomics

U Distler, J Kuharev, S Tenzer - Expert review of proteomics, 2014 - Taylor & Francis
Mass spectrometry-based proteomics greatly benefited from recent improvements in
instrument performance and the development of bioinformatics solutions facilitating the high …

Studying macromolecular complex stoichiometries by peptide‐based mass spectrometry

I Wohlgemuth, C Lenz, H Urlaub - Proteomics, 2015 - Wiley Online Library
A majority of cellular functions are carried out by macromolecular complexes. A host of
biochemical and spectroscopic methods exists to characterize especially protein/protein …

A metastable rRNA junction essential for bacterial 30S biogenesis

IM Sharma, MC Rappé, B Addepalli… - Nucleic Acids …, 2018 - academic.oup.com
Tertiary sequence motifs encode interactions between RNA helices that create the three-
dimensional structures of ribosomal subunits. A Right Angle motif at the junction between …

Stepped collisional energy MSAll: an analytical approach for optimal MS/MS acquisition of complex mixture with diverse physicochemical properties

H Ye, L Wang, L Zhu, D Sun, X Luo… - Journal of Mass …, 2016 - Wiley Online Library
The analysis of complex mixtures is becoming increasingly important in various fields, such
as nutrition, medicinal plants and metabolomics. The components contained in such …

A novel protocol for enzymatic digestion based on covalent binding by protein immobilization

Q Qi, G Yan, C Deng, X Zhang - Analytical and bioanalytical chemistry, 2016 - Springer
The process of protein digestion is a critical step for successful protein identification in
proteomic analysis. Many efforts have been dedicated to enhancing the digestion efficiency …