Genetic data have become increasingly complex within the past decade, leading
researchers to pursue increasingly complex questions, such as those involving epistatic …

Long DNA segments shared between two individuals, known as identity-by-descent (IBD),
reveal recent genealogical connections. Here we introduce ancIBD, a method for identifying …

Genome-wide genealogies compactly represent the evolutionary history of a set of genomes
and inferring them from genetic data has the potential to facilitate a wide range of analyses …

Analyses of data from genome-wide association studies on unrelated individuals have
shown that, for human traits and diseases, approximately one-third to two-thirds of …

Simple Summary The number of local farm animal breeds is declining worldwide. However,
these breeds have different degrees of genetic diversity. Measuring genetic diversity is …

Population stratification continues to bias the results of genome-wide association studies
(GWAS). When these results are used to construct polygenic scores, even subtle biases can …

Exome association studies to date have generally been underpowered to systematically
evaluate the phenotypic impact of very rare coding variants. We leveraged extensive …

Common genetic variants explain less variation in complex phenotypes than inferred from
family-based studies, and there is a debate on the source of this 'missing heritability'. We …

Malaria genomic surveillance often estimates parasite genetic relatedness using metrics
such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial …

We developed a novel method for efficiently estimating time-varying selection coefficients
from genome-wide ancient DNA data. In simulations, our method accurately recovers …