Trends in insulin resistance: insights into mechanisms and therapeutic strategy

M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Senescent adipocytes and type 2 diabetes–current knowledge and perspective concepts

W Kruczkowska, J Gałęziewska, M Kciuk… - Biomolecular …, 2024 - degruyter.com
Among civilization diseases, the number of individuals suffering from type 2 diabetes
(T2DM) is expected to increase to more than a billion in less than 20 years, which is …

Identification of key ferroptosis genes in diabetic retinopathy based on bioinformatics analysis

Y Huang, J Peng, Q Liang - Plos one, 2023 - journals.plos.org
Objectives Diabetic retinopathy (DR) is a retinal microvascular disease associated with
diabetes. Ferroptosis is a new type of programmed cell death that may participate in the …

The impact of PPARγ and ApoE gene polymorphisms on susceptibility to diabetic kidney disease in type 2 diabetes mellitus: a meta-analysis

B Taurbekova, K Mukhtarova, Z Salpynov… - BMC nephrology, 2024 - Springer
Background Globally, diabetic kidney disease (DKD) has become the leading cause of end-
stage renal disease, imposing substantial social and economic costs. This meta-analysis …

[HTML][HTML] Investigation of polymorphism role in protein structure and function for selected cancer and diabetes disease; a rationale to selection of targets for insilico drug …

CB Olowosoke, TA Ibisanmi, CJ Eze… - Informatics in Medicine …, 2023 - Elsevier
Objectives Cancer and diabetes are two diseases known to bypass socio-demographic
segregation, hence the increased focus on their molecular mechanism for therapeutic …

[HTML][HTML] Роль полиморфизма rs1801282 гена PPARG в прогнозировании риска развития нарушений углеводного обмена и выборе тактики лечения

КБ Хасанова, МС Медведева, ЕВ Валеева… - Consilium …, 2022 - cyberleninka.ru
Ген PPARG представляет наибольшую ценность в прогнозировании развития
нарушений углеводного обмена и ответа пациентов на варианты проводимой терапии …

Genetic variants related to insulin metabolism are associated with gestational diabetes mellitus

R Bhushan, S Haque, RK Gupta, A Rani, A Diwakar… - Gene, 2024 - Elsevier
The current study sought to investigate the associations of common genetic risk variants with
gestational diabetes mellitus (GDM) risk in the north Indian population and to evaluate their …

A Rare Olive Compound Oleacein Improves Lipid and Glucose Metabolism, and Inflammatory Functions: A Comprehensive Whole-Genome Transcriptomics Analysis …

R Wang, M Ganbold, F Ferdousi, K Tominaga… - International Journal of …, 2023 - mdpi.com
Oleacein (OLE), a rare natural compound found in unfiltered extra virgin olive oil, has been
shown to have anti-inflammatory and anti-obesity properties. However, little is known …

四逆散“异病同治” 的网络药理学作用机制文献综述

张翔宇, 余子悦, 李苗博, 刘明, 田金徽 - 2023 - ir.lzu.edu.cn
摘要目的基于发表的网络药理学研究探讨四逆散对肝癌, 慢性肝炎, 脂肪肝,
桥本甲状腺炎等疾病“异病同治” 的作用机制. 方法检索四逆散网络药理学研究 …

The role of the rs1801282 PPARG polymorphic marker in the prediction and choice of carbohydrate metabolism disorders management: A review

KB Khasanova, MS Medvedeva… - Consilium …, 2022 - consilium.orscience.ru
The PPARG gene has the great value in predicting of carbohydrate metabolism disorders
development and the patients' response to different therapy options. The article presents the …