The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Plastics play an essential role in modern society; however, the relentless growth of their
production is threatening both human health and ecosystems. As a result, there are …

Conspectus Electron-deficient boron-based catalysts with metal-free but metallomimetic
characteristics provide a versatile platform for chemical transformations. However, their …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Biological cells are highly organized, with numerous subcellular compartments.
Phosphorylation has been hypothesized as a means to control the assembly/disassembly of …

BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

1.1. Inspired by Nature In many enzymes, such as ureases (Figure 1), two or more metal
centers are poised in close proximity to activate both electrophilic and nucleophilic …

The impetus to modeling of enzyme active sites comes from their potential to provide insight
to the mechanistic pathways of the native enzymes, establish the role of that particular metal …

Abstract Poly (lactic acid)(PLA) is by far the most commonly produced biodegradable
polyester. Metal-mediated ring opening polymerization of lactide is the most studied route for …