High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage

Y Lai, JP Koelmel, DI Walker, EJ Price… - Environmental …, 2024 - ACS Publications
In the modern “omics” era, measurement of the human exposome is a critical missing link
between genetic drivers and disease outcomes. High-resolution mass spectrometry …

Suspect screening analysis by tandem mass spectra from metabolomics to exposomics

C Shi, J Yang, Z You, Z Zhang, M Fang - TrAC Trends in Analytical …, 2024 - Elsevier
Compared to metabolomics, exposomics imposes more stringent requirements for analytical
methods, owing to the trace concentrations of exposure chemicals and their complex …

Using Machine Learning to Construct the Blood–Follicle Distribution Models of Various Trace Elements and Explore the Transport-Related Pathways with Multiomics …

G Zhang, W Lin, N Gao, C Lan, M Ren… - Environmental …, 2024 - ACS Publications
Permeabilities of various trace elements (TEs) through the blood–follicle barrier (BFB) play
an important role in oocyte development. However, it has not been comprehensively …

Human Biomonitoring of Environmental Chemicals among Elderly in Wuhan, China: Prioritizing Risks Using EPA's ToxCast Database

M Wang, X Wang, K Huang, B Han, R Li… - Environmental …, 2024 - ACS Publications
In line with the “healthy aging” principle, we aim to assess the exposure map and health
risks of environmental chemicals in the elderly. Blood samples from 918 elderly individuals …

[HTML][HTML] The effect of endocrine-disrupting chemicals in follicular fluid: The insights from oocyte to fertilization

J Li, L Zhou, S Huang, T Duan, J Xie, X Li, L Deng… - Environment …, 2024 - Elsevier
Endocrine-disrupting chemicals (EDCs) exhibited the detriment in female reproductive
health. Our objective was to investigate the individual and mixture effects of EDCs present in …

Toxicological Study of Human Exposure to Mixtures of Chemicals: Challenges and Approaches

M Nian, G Braun, BI Escher, M Fang - Environmental Science & …, 2024 - ACS Publications
Humans are exposed to highly diverse mixtures of complex and often unknown
compositions, which may adversely impact their health. There is a lack of guidance on how …

[HTML][HTML] Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

Ž Tkalec, JP Antignac, N Bandow, FM Béen… - Environment …, 2024 - Elsevier
The chemical burden on the environment and human population is increasing.
Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent …

Ascertaining sensitive exposure biomarkers of various metal (loid) s to embryo implantation

M Ren, T Wu, S Yang, N Gao, C Lan, H Zhang… - Environmental …, 2024 - Elsevier
Close relationships exist between metal (loid) s exposure and embryo implantation failure
(EIF) from animal and epidemiological studies. However, there are still inconsistent results …

[HTML][HTML] Systematic approaches to machine learning models for predicting pesticide toxicity

G Anandhi, M Iyapparaja - Heliyon, 2024 - cell.com
Pesticides play an important role in modern agriculture by protecting crops from pests and
diseases. However, the negative consequences of pesticides, such as environmental …

Thyroid Hormone Biomonitoring: A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals

S Chen, M Yu, Y Yao, Y Li, A He, Z Zhou… - Environment & …, 2024 - ACS Publications
The thyroid is an essential endocrine organ in human body, and thyroid hormones (THs) are
pivotal signaling molecules and mediators in various physiological processes. THs …