The neuropsychological effects of naturally occurring psychoactive chemicals have been
recognized for millennia. Hallucinogens, which include naturally occurring chemicals such …

Hallucinogens (psychedelics) are psychoactive substances that powerfully alter perception,
mood, and a host of cognitive processes. They are considered physiologically safe and do …

G protein-coupled receptors (GPCRs) are seven transmembrane proteins that form the
largest single family of integral membrane receptors. GPCRs transduce information provided …

Insects provide an attractive system for the study of olfactory sensory perception. We have
identified a novel family of seven transmembrane domain proteins, encoded by 100 to 200 …

The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has
shared signaling properties that contribute to the definition of the receptor class, although …

Vascular endothelial cells undergo morphogenesis into capillary networks in response to
angiogenic factors. We show here that sphingosine-1-phosphate (SPP), a platelet-derived …

G protein-coupled, seven-transmembrane segment receptors (GPCRs or 7TM receptors),
with more than 1000 different members, comprise the largest superfamily of proteins in the …

GnRH and its analogs are used extensively for the treatment of hormone-dependent
diseases and assisted reproductive techniques. They also have potential as novel …

GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …

Functional selectivity is the term that describes drugs that cause markedly different signaling
through a single receptor (eg, full agonist at one pathway and antagonist at a second). It has …