The function and phenotype of macrophages are intimately linked with pathogen detection.
On sensing pathogen-derived signals and molecules, macrophages undergo a carefully …

Understanding changes in pathogen behavior (eg increased virulence, a shift in
transmission channel) is critical for the public health management of emerging infectious …

It has been noted by the World Health Organisation that cases of tuberculosis in 2022
globally numbered 10.6 million, resulting in 1.3 million deaths, such that TB is one of the …

Background & Aims Metabolic reprogramming is essential for the activation and functions of
macrophages, including bacterial killing and cytokine production. Bromodomain-containing …

Macrophage populations exist on a spectrum between the proinflammatory M1 and
proresolution M2 states and have demonstrated the ability to reprogram between them after …

Omega-3 polyunsaturated fatty acids (n-3 PUFA), such as the eicosapentaenoic acid (EPA)
and docosahexaenoic acid (DHA), are reported to beneficially affect the intestinal immunity …

Many pathogenic organisms need to reach either an intracellular compartment or the
cytoplasm of a target cell for their survival, replication or immune system evasion …

Salmonella enterica is a group of facultative, gram-negative bacteria. Recently, new
evidence indicated that Salmonella could reprogram the host metabolism to increase energy …

Salmonella Enteritidis is an important intracellular pathogen, which can cause
gastroenteritis in humans and animals and threaten life and health. S. Enteritidis proliferates …

Salmonella typhimurium (S. typhimurium), a prevalent cause of foodborne infection, induces
significant changes in the host transcriptome and metabolome. The lack of therapeutics with …