The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies

N Herring, M Kalla, DJ Paterson - Nature Reviews Cardiology, 2019 - nature.com
Research into cardiac autonomic control has received great interest in the past 20 years,
and we are now at a critical juncture with regard to the clinical translation of the experimental …

The role of the autonomic nervous system in cardiac arrhythmias: the neuro-cardiac axis, more foe than friend?

AA Manolis, TA Manolis, EJ Apostolopoulos… - Trends in cardiovascular …, 2021 - Elsevier
The autonomic nervous system (ANS) with its two limbs, the sympathetic (SNS) and
parasympathetic nervous system (PSNS), plays a critical role in the modulation of cardiac …

Innervation and neuronal control of the mammalian sinoatrial node a comprehensive atlas

P Hanna, MJ Dacey, J Brennan, A Moss… - Circulation …, 2021 - Am Heart Assoc
Rationale: Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative
techniques to modulate control of cardiac function are currently being studied in patients …

Neuroscientific therapies for atrial fibrillation

P Hanna, E Buch, S Stavrakis, C Meyer… - Cardiovascular …, 2021 - academic.oup.com
The cardiac autonomic nervous system (ANS) plays an integral role in normal cardiac
physiology as well as in disease states that cause cardiac arrhythmias. The cardiac ANS …

Aging impairs the neurovascular interface in the heart

JUG Wagner, LS Tombor, PF Malacarne… - Science, 2023 - science.org
Aging is a major risk factor for impaired cardiovascular health. Because the aging
myocardium is characterized by microcirculatory dysfunction, and because nerves align with …

Research opportunities in autonomic neural mechanisms of cardiopulmonary regulation: a report from the national heart, lung, and blood institute and the national …

R Mehra, OA Tjurmina, OA Ajijola, R Arora… - Basic to Translational …, 2022 - jacc.org
This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in
partnership with the Office of Strategic Coordination of the Office of the National Institutes of …

Autonomic control of ventricular function in health and disease: current state of the art

VYH van Weperen, CM Ripplinger… - Clinical Autonomic …, 2023 - Springer
Purpose Cardiac autonomic dysfunction is one of the main pillars of cardiovascular
pathophysiology. The purpose of this review is to provide an overview of the current state of …

cAMP Imaging at Ryanodine Receptors Reveals β2-Adrenoceptor Driven Arrhythmias

F Berisha, KR Götz, JW Wegener… - Circulation …, 2021 - Am Heart Assoc
Rationale: 3′, 5′-cAMP is a ubiquitous second messenger which, upon β-AR (β-
adrenergic receptor) stimulation, acts in microdomains to regulate cardiac excitation …

Cardioneuroablation using epicardial pulsed field ablation for the treatment of atrial fibrillation

B O'Brien, J Reilly, K Coffey… - Journal of …, 2023 - mdpi.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people
worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a …

Intrinsic cardiac autonomic nervous system: what do clinical electrophysiologists need to know about the “heart brain”?

T Aksu, R Gopinathannair, D Gupta… - Journal of …, 2021 - Wiley Online Library
It is increasingly recognized that the autonomic nervous system (ANS) is a major contributor
in many cardiac arrhythmias. Cardiac ANS can be divided into extrinsic and intrinsic parts …