Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and
neuronal death are commonly found in the brains of patients with clinical Parkinson disease …

Cognitive aging is often described in the context of loss or decline. Emerging research
suggests that the story is more complex, with older adults showing both losses and gains in …

The relationship of cortical structure and specific neuronal circuitry to global brain function,
particularly its perturbations related to the development and progression of neuropathology …

The default mode network (DMN) of the brain consists of areas that are typically more active
during rest than during active task performance. Recently however, this network has been …

In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

The world is aging and, as the elderly population increases, age-related cognitive decline
emerges as a major concern. Neuroimaging techniques, such as functional magnetic …

Structural brain markers are studied extensively in the field of neurodegeneration, but are
thought to occur rather late in the process. Functional measures such as functional …

The human brain undergoes both morphological and functional modifications across the
human lifespan. It is important to understand the aspects of brain reorganization that are …

Complex mental activity induces improvements in cognition, brain function, and structure in
animals and young adults. It is not clear to what extent the aging brain is capable of such …