mTOR inhibitors in the pharmacologic management of tuberous sclerosis complex and their potential role in other rare neurodevelopmental disorders

DN Franz, JK Capal - Orphanet journal of rare diseases, 2017 - Springer
Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder that affects
multiple organ systems throughout the body. Dysregulation of the mammalian target of …

Persistent treatment resistance in genetic generalized epilepsy: a long‐term outcome study in a tertiary epilepsy center

E Cerulli Irelli, A Morano, FA Barone, G Fisco… - …, 2020 - Wiley Online Library
Objective To assess prognostic patterns and investigate clinical and
electroencephalography (EEG) variables associated with persistent treatment resistance in …

Clinical prediction models for treatment outcomes in newly diagnosed epilepsy: A systematic review

C Ratcliffe, V Pradeep, A Marson, SS Keller… - …, 2024 - Wiley Online Library
Up to 35% of individuals diagnosed with epilepsy continue to have seizures despite
treatment, commonly referred to as drug‐resistant epilepsy. Uncontrolled seizures can …

Seizure outcome trajectories in a well‐defined cohort of newly diagnosed juvenile myoclonic epilepsy patients

E Cerulli Irelli, A Morano, B Orlando… - Acta Neurologica …, 2022 - Wiley Online Library
Objective To investigate the temporal course of medication response and associated
prognostic factors in a cohort of juvenile myoclonic epilepsy (JME) patients over a long‐term …

Epilepsy diagnostic and treatment needs identified with a collaborative database involving tertiary centers in France

M Chipaux, W Szurhaj, L Vercueil, M Milh… - …, 2016 - Wiley Online Library
Objective To obtain perspective on epilepsy in patients referred to tertiary centers in France,
and describe etiology, epilepsy syndromes, and identify factors of drug resistance and …

Glucose metabolic profile by visual assessment combined with statistical parametric mapping analysis in pediatric patients with epilepsy

Y Zhu, J Feng, S Wu, H Hou, J Ji, K Zhang… - Journal of Nuclear …, 2017 - Soc Nuclear Med
PET with 18F-FDG has been used for presurgical localization of epileptogenic foci; however,
in nonsurgical patients, the correlation between cerebral glucose metabolism and clinical …

Course and prognosis of adult-onset epilepsy in Brazil: A cohort study

ALF Caprara, JP Rissardo, MTB Leite, JOF Silveira… - Epilepsy & Behavior, 2020 - Elsevier
Background Most of the epilepsy longitudinal studies have analyzed children. However, in
endemic regions, such as Brazil, neurocysticercosis accounts for many adult-onset epilepsy …

The epidemiological characteristics of epilepsy in the province of Khyber Pakhtunkhwa, Pakistan

S Ullah, N Ali, A Khan, S Ali, HR Nazish - Frontiers in neurology, 2018 - frontiersin.org
Previous studies have shown that Khyber Pakhtunkhwa, Pakistan has a high incidence of
epilepsy and a high proportion of low socioeconomic background and high treatment gap …

[HTML][HTML] Seizure outcome and epilepsy patterns in patients with cerebral palsy

NT El Tantawi, DS Abd Elmegid, E Atef - Seizure, 2019 - Elsevier
Purpose The aim of the present study was to investigate epilepsy patterns and outcomes in
patients with cerebral palsy (CP) and identify the variables that determine remission …

Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case‐Control Study

I Mangunatmadja, RM Indra, DP Widodo… - Behavioural …, 2021 - Wiley Online Library
Background. Children with epilepsy with onset above five years encompass distinct
epidemiological and clinical characteristics that may have specific risk factors for resistance …