Simple Summary Thymine DNA Glycosylase (TDG) is a DNA repair protein that plays an
important role in gene regulation. Recent studies have shown that TDG interacts with …

Chemical alterations in DNA induced by genotoxic factors can have a complex nature such
as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions …

Oxidation of DNA bases generates mutagenic and cytotoxic lesions that are implicated in
cancer and other diseases. Oxidative base lesions, including 7, 8-dihydro-8-oxoguanine …

Reactive oxygen species attack DNA to produce 7, 8-dihyro-8-oxoguanine (oxoG) and 7, 8-
dihydro-8-oxoadenine (oxoA) as major lesions. The structural basis for the mutagenicity of …

In cellular organisms composition of DNA is constrained to only four nucleobases A, G, T
and C, except for minor DNA base modifications such as methylation which serves for …

Species survival depends on the faithful replication of genetic information, which is
continually monitored and maintained by DNA repair pathways that correct replication errors …

Base excision DNA repair (BER) is an important process used by all living organisms to
remove nonbulky lesions from DNA. BER is usually initiated by DNA glycosylases that …

Protein moonlighting is a phenomenon in which a single polypeptide chain can perform a
number of different unrelated functions. Here we present our analysis of moonlighting in the …

Introduction: Cardiac fibroblast activation is a pivotal cellular event in cardiac fibrosis.
Numerous studies have indicated that epigenetic modifications control cardiac fibroblast …

Dietary exposure to aflatoxins is a significant risk factor in the development of hepatocellular
carcinomas. Following bioactivation by microsomal P450s, the reaction of aflatoxin B1 …