Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis

Y Han, H Xie, Y Liu, P Gao, X Yang, Z Shen - Cardiovascular Diabetology, 2019 - Springer
Background Metformin is the most widely prescribed drug to lower glucose and has a
definitive effect on the cardiovascular system. The goal of this systematic review and meta …

Cholesterol-rich lipid rafts as platforms for SARS-CoV-2 entry

SN Palacios-Rápalo, LA De Jesus-Gonzalez… - Frontiers in …, 2021 - frontiersin.org
Since its appearance, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2),
the causal agent of Coronavirus Disease 2019 (COVID-19), represents a global problem for …

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

EA Day, RJ Ford, BK Smith… - Nature …, 2019 - nature.com
Metformin is the most commonly prescribed medication for type 2 diabetes, owing to its
glucose-lowering effects, which are mediated through the suppression of hepatic glucose …

The current and potential therapeutic use of metformin—the good old drug

J Drzewoski, M Hanefeld - Pharmaceuticals, 2021 - mdpi.com
Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

Metformin, cognitive function, and changes in the gut microbiome

M Rosell-Díaz, JM Fernández-Real - Endocrine reviews, 2024 - academic.oup.com
The decline in cognitive function and the prevalence of neurodegenerative disorders are
among the most serious threats to health in old age. The prevalence of dementia has …

Metformin for cardiovascular protection, inflammatory bowel disease, osteoporosis, periodontitis, polycystic ovarian syndrome, neurodegeneration, cancer …

M Ala, M Ala - ACS pharmacology & translational science, 2021 - ACS Publications
Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

[HTML][HTML] Weight-centric treatment of type 2 diabetes mellitus

W Ghusn, MD Hurtado, A Acosta - Obesity Pillars, 2022 - Elsevier
Background Chronic non-communicable diseases (CNCD) represent a major cause of
morbidity and mortality. Type 2 diabetes mellitus (T2DM) is one of the most prevalent CNCD …

The antiviral effect of metformin on zika and dengue virus infection

CN Farfan-Morales, CD Cordero-Rivera… - Scientific Reports, 2021 - nature.com
The Dengue (DENV) and zika (ZIKV) virus infections are currently a public health concern.
At present, there is no treatment or a safe and effective vaccine for these viruses. Hence, the …

Exercise and Metformin Intervention Prevents Lipotoxicity‐Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO‐1 …

Y Zhang, Y Liu, X Liu, X Yuan, M Xiang… - Oxidative Medicine …, 2022 - Wiley Online Library
Objective. Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) commonly
coexist and act synergistically to drive adverse clinical outcomes. This study is aimed at …

The use of metformin to increase the human healthspan

V Piskovatska, KB Storey, AM Vaiserman… - Reviews on New Drug …, 2020 - Springer
Metformin is a safe, effective and useful drug for glucose management in patients with
diabetes. However in recent years, more attention has been paid to the possibility of using …