A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …

Cells respond to stress stimuli through coordinated changes in gene expression. The
regulation of translation is often used under these circumstances because it allows …

The'inhibitor of apoptosis'(IAP) gene family, which was discovered less than a decade ago,
encodes a group of structurally related proteins that, in addition to their ability to suppress …

Emerging evidence suggests that the ribosome has a regulatory function in directing how
the genome is translated in time and space. However, how this regulation is encoded in the …

Initiation of translation of most eukaryotic mRNAs commences with 5 end–dependent
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …

The retina has long been regarded as 'an approachable part of the brain'for investigating
neurosensory processes. Cell biologists are now capitalizing on the accessibility of the …

Translation initiation of most mammalian mRNAs is mediated by a 5′ cap structure that
binds eukaryotic initiation factor 4E (eIF4E). However, inactivation of eIF4E does not impair …

Over the years, studies have focused on the transcriptional regulation of oncogenesis. More
recently, a growing emphasis has been placed on translational control. The Ras and Akt …

Current understanding of the molecular basis of pathogenesis of foot-and-mouth disease
(FMD) has been achieved through over 100 years of study into the biology of the etiologic …

Vanishing white matter disease (VWM) is one of the most prevalent inherited childhood
leucoencephalopathies. The classical phenotype is characterised by early childhood onset …