Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

This article will provide an updated review of spermatogonial stem cells and their role in
maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial …

Spermatogonial stem cells (SSCs) are the foundation for spermatogenesis and, thus,
preservation of a species. Because of stem cell rarity, studying their self-renewal is greatly …

In many tissues, homeostasis is maintained by physical contact between stem cells and an
anatomically defined niche. However, how stem cell homeostasis is achieved in …

Sex in mammals is genetically determined and is defined at the cellular level by sex
chromosome complement (XY males and XX females). The Y chromosome–linked gene sex …

Objective To determine the molecular characteristics of human spermatogonia and optimize
methods to enrich spermatogonial stem cells (SSCs). Design Laboratory study using human …

Humans, mice, and even kangaroos have an XX female: XY male system of sex
determination, in which the Y harbors a male-dominant sex-determining gene SRY. Birds …

In the mammalian testis, spermatogenesis is initiated from a subset of stem cells belonging
to undifferentiated type A spermatogonia. In spite of the biologic significance of …

The long-term production of billions of spermatozoa relies on the regulated proliferation and
differentiation of spermatogonial stem cells (SSCs). To date only a few factors are known to …

Spermatogonial self-renewal and differentiation are essential for male fertility and
reproduction. We discovered that germ cell specific genes Sohlh1 and Sohlh2, encode basic …