Aims Bleomycin, an important toxic anti-cancer agent, induces pulmonary fibrosis. The
significance of oxidative stress and inflammation in promoting of bleomycin-induced …

Introduction Benign prostatic hyperplasia (BPH) is a major urologic problem that mostly
develops in older males. Oxidative stress and inflammation influence the occurrence of BPH …

Purpose Cyclophosphamide is an alkylating agent with nephrotoxicity that constrains its
clinical application. Berberine is an isoquinoline derivative alkaloid with biological functions …

Gentamicin is an essential aminoglycoside antibiotic, but it is only used to treat severe
bacterial infections due to its high nephrotoxicity in patients. We evaluated the preventive …

Background: Mercury has a variety of industrial applications and is well-known for its
hematotoxic, hepatotoxic, neurotoxic, nephrotoxic, and genotoxic effects. Objectives: This …

Background Arsenic is ubiquitous in the environment, and long-or short-term exposure
through water, food, and occupational sources can contribute to oxidative stress-related …

Background: Methotrexate as a chemotherapy agent causes oxidative stress in the liver.
Chicory (Cichorium intybus), a member of the Asteraceae family, is a well-known herb …

The new therapeutic solutions for breast cancer treatment are needed, for example,
combined therapy consisted of several drugs that characterize different mechanisms of …

Cyclophosphamide (CP) is widely described in the management of several nonneoplastic
and neoplastic disorders. Renal damage is the most reported toxic effect of CP in clinical …

Epigenetic mechanisms are the most important factors contributing to both the development
and metastasis of cancer cells. We aimed to scrutinize the role of epigenetic alternations of …