The anatomical basis for transcutaneous auricular vagus nerve stimulation

MF Butt, A Albusoda, AD Farmer, Q Aziz - Journal of anatomy, 2020 - Wiley Online Library
The array of end organ innervations of the vagus nerve, coupled with increased basic
science evidence, has led to vagus nerve stimulation (VNS) being explored as a …

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

MJ Betts, E Kirilina, MCG Otaduy, D Ivanov… - Brain, 2019 - academic.oup.com
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Optimization of transcutaneous vagus nerve stimulation using functional MRI

N Yakunina, SS Kim, EC Nam - Neuromodulation: technology at the neural …, 2017 - Elsevier
Objective/Hypothesis Vagus nerve stimulation (VNS) is an established therapy for drug-
resistant epilepsy, depression, and a number of other disorders. Transcutaneous stimulation …

Pupil diameter covaries with BOLD activity in human locus coeruleus

PR Murphy, RG O'connell, M O'sullivan… - Human brain …, 2014 - Wiley Online Library
The locus coeruleus‐noradrenergic (LC–NA) neuromodulatory system has been implicated
in a broad array of cognitive processes, yet scope for investigating this system's function in …

Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: a concurrent taVNS/fMRI study and …

BW Badran, LT Dowdle, OJ Mithoefer, NT LaBate… - Brain stimulation, 2018 - Elsevier
Background Electrical stimulation of the auricular branch of the vagus nerve (ABVN) via
transcutaneous auricular vagus nerve stimulation (taVNS) may influence afferent vagal …

Declining locus coeruleus–dopaminergic and noradrenergic modulation of long-term memory in aging and Alzheimer's disease

MJ Dahl, A Kulesza, M Werkle-Bergner… - … & Biobehavioral Reviews, 2023 - Elsevier
Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Orienting and reorienting: the locus coeruleus mediates cognition through arousal

SJ Sara, S Bouret - Neuron, 2012 - cell.com
Mood, motivation, attention, and arousal are behavioral states having a profound impact on
cognition. Behavioral states are mediated though the peripheral nervous system and …

Dynamic modulation of decision biases by brainstem arousal systems

JW de Gee, O Colizoli, NA Kloosterman, T Knapen… - elife, 2017 - elifesciences.org
Decision-makers often arrive at different choices when faced with repeated presentations of
the same evidence. Variability of behavior is commonly attributed to noise in the brain's …

The ascending arousal system shapes neural dynamics to mediate awareness of cognitive states

BR Munn, EJ Müller, G Wainstein, JM Shine - Nature communications, 2021 - nature.com
Abstract Models of cognitive function typically focus on the cerebral cortex and hence
overlook functional links to subcortical structures. This view does not consider the role of the …

Understanding the exploration–exploitation dilemma: An fMRI study of attention control and decision‐making performance

D Laureiro‐Martínez, S Brusoni… - Strategic …, 2015 - Wiley Online Library
This paper studies the cognitive processes that enable decision makers to switch between
exploitation and exploration. We use functional magnetic resonance imaging (fMRI) in a …