The study of protein folding mechanism is a challenge in molecular biology, which is of great
significance for revealing the movement rules of biological macromolecules, understanding …

Nearly all biological processes, including strictly regulated protein–protein interactions
fundamental in cell signaling, occur inside living cells where the concentration of …

The zona pellucida (ZP) surrounding the oocyte is an extracellular fibrillar matrix that plays
critical roles during fertilization including species-specific gamete recognition and protection …

Oligomerization by 3D domain swapping is found in a variety of proteins of diverse size, fold
and function. In the early 1960s this phenomenon was postulated for the oligomers of …

Renal tubular epithelial cells (RTEC) apoptosis, which plays a key role in the pathogenesis
and progression of diabetic nephropathy (DN), is believed to be contributive to the …

The human pathogen Helicobacter pylori requires nickel for colonization of the acidic
environment of the stomach. HypA, a Ni metallochaperone that is typically associated with …

Activation of the T cell receptor (TCR) results in binding of the adapter protein Nck
(noncatalytic region of tyrosine kinase) to the CD3ϵ subunit of the TCR. The interaction was …

Abstract Acylphosphatase (AcP, EC 3.6. 1.7) is a small model protein conformed by a
ferredoxin-like fold, profoundly studied to get insights into protein folding and aggregation …

Metalloproteins are ubiquitous in all living organisms and take part in a very wide range of
biological processes. For this reason, their experimental characterization is crucial to obtain …

Understanding the role of naturally occurring protective osmolytes, such as trimethylamine N-
oxide (TMAO), in the growth of amyloid fibrils implicated in neurodegenerative diseases is …